8(9)-EET
8(9)-EET is a major cytochrome P450 (CYP450) metabolite in the renal cortex. It activates PPARα in HEK293 cells when used at a concentration of 1 μM but inhibits NF-κB activity induced by IL-1β in a PPARα-dependent and -independent fashion[3]. It is also a substrate of COX-1 and COX-2, as measured by oxygen consumption and product formation assays when used at a concentration of 50 μM [4].
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cell25sk34317